Medicinal mushrooms have been immensely popular in Asia for millennia. Today, Americans are waking up to these powerful nutraceuticals. In the wake of this new awareness follow issues of product quality claims made by competing brands.
All species of medicinal mushrooms appear haunted by this issue. Particularly so, it seems, is red reishi (Ganoderma lucidum), the oldest medicinal mushroom in Traditional Chinese Medicine. Please note, however, that the information in this article applies generally to all medicinal mushroom species.
First off, stay clear of cheap, mass-produced medicinal mushrooms. If they are just dried and pulverized, then the medicinal compounds are still inaccessible behind the mushrooms’ cell-walls. You’ll be wasting your money on inert matter.
But even among the truly effective therapeutic brands, which are plentiful, there are important differences. Each seems to claim superiority over other brands, not surprisingly, because why else would anyone buy them? This article aims to clarify the confusion of conflicting and sometimes misleading information that is out there.
There are primarily three ways to extract the medicinal compounds from red reishi. Each method pulls out different compounds, all of which have been proven by scientific research to be therapeutically important.
1. Hot Water Extraction (polysaccharides, etc.)
2. Alcohol Extraction (triterpenoids, sterols)
3. Fermented (arabinoxylanes, etc.)
The most important hot water extracted compounds are the polysaccharides. Studies have shown them to possess strong anti-tumor properties, help boost immune system and be powerful antioxidants. [1]
Through alcohol extraction, we get triterpenoids, a large group of lipids with many sub-groups. Research shows triterpenoids help regulate clotting, blood pressure and cholesterol. More importantly, they are the anti-inflammatory compounds that are the reason why reishi often gets recommended for arthritis, asthma and allergies. [1]
And then there are the new and unique medicinal compounds that get created when reishi is fermented. These “secondary metabolites” have their own therapeutic properties, different from the first two groups, including anti-tumor, immune support and blood-sugar balance. [2]
Since this article is not intended to elevate any one brand over another, no brand names will be mentioned. Nevertheless, the author does know of two highly reputed brands (American and Japanese) that claim only hot water extracted red reishi is of any value and that alcohol extracts are useless.
They do that, of course, because they wish to sell their products. However, there is no scientific validity to those claims. All three extraction methods listed above yield important medicinal compounds.
To find the best red reishi products, look for those brands that use at least the first two extraction methods in combination: Hot Water Extraction and Alcohol Extraction. Better yet would be brands that incorporate all three extraction methods, including Fermentation.
As a last point, when you look for the best reishi extract, one thing to look at is the form it comes in. For example, any reishi extract that fully dissolves in a water-based liquid such as coffee probably only contains hot water extracted reishi. So while reishi/ganoderma coffee certainly makes for a superbly delicious and healthy cup loaded with polysaccharides, it won’t include the important anti-inflammatory triterpenoids.
Alcohol tinctures, on the other hand, are well worth considering because they may be a blend of water and alcohol extracts. The way to tell is if the tincture is cloudy. When water-soluble polysaccharides get mixed with alcohol, they fall out of solution. Cloudiness in an alcohol tincture indicates high polysaccharide content. Just shake before taking. Tablets and capsules can contain hot water extract, alcohol extract or both. You need to find out from the manufacturer.
[1] Boh B, Berovic M, Zhang J, Zhi-Bin L. “Ganoderma lucidum and its pharmaceutically active compounds.” Biotechnology Annual Review 2007;13:265-301.
[2] Tang YJ, Zhang W, Zhong JJ. “Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.” Bioresour Technol. 2009 Mar;100(5):1852-9.
Dr. Rafael has worked with natural health since the early 90’s, currently focusing on medicinal mushrooms. He partners with Cordyceps Reishi Extracts, LLC on red reishi extract and cordyceps extract plus the increasingly popular mesima and more.








